Right now, I've a self-reliant Vampire Priestess (actually High Priest) of Death magic in ZAngband 2.4. She's hanging around level 28 right now, as I very, very slowly advance to test her limits.
All her stats are maxed for purposes of biological improvement, now requiring additional magic equipment to further improve. All her mutations thus far have been invariably helpful. Her equipment seems universally resistant to acid, and probably several other things; in fact, it's hard to find an item on her person which isn't named.
I can't recall how many hundreds of vampire priestesses died before her, but none got this far. This without cheating at all. It's nice!
Basically, I play this character because you never run out of food, the experience handicap isn't too significant, and at Level 33 you can quickly work up the cash by Poison Branding to buy out the Black Markets. Which is, by the way, how I filled out her stats.
Eventually, she'll get caught with her pants down, her stats plummeting anywhere she isn't naturally resistant as some nasty monster wipes out her equipment by some bizarre means possibly involving significant mutation, and I'll be very, very sad.
Since I want her to be way too powerful, I'm taking it slow, not looking forward to such beasties.